Resting and activated states of the B cell antigen receptor
نویسندگان
چکیده
منابع مشابه
the investigation of the relationship between type a and type b personalities and quality of translation
چکیده ندارد.
Autoantigen-B cell antigen receptor interactions that regulate expression of B cell antigen receptor Loci.
Levels of AgR (BCR) expression are regulated during B cell development, activation, and induction of tolerance. The mechanisms responsible for and consequences of this regulation are poorly understood. We have described a class of DNA-based autoantigen-reactive B cell that down-regulates BCR expression during development to mature follicular phenotype. In this study, we show that at immature st...
متن کاملB-cell development and antigen receptor signalling.
B-cell development and function requires the products of the Vav family of genes. Vav proteins act as key components of the antigen receptor signal transduction machinery by integration of signals that control the cell cycle, differentiation and apoptosis. At the molecular level, Vav proteins regulate small-molecular-mass GTPases, phosphoinositide 3-kinase, TEC family tyrosine kinases and intra...
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Antigen presentation by resting splenic B cells has been shown previously to induce T helper 1 cell (Th1) anergy. In contrast to expectations, it was found here that B cells treated with F(ab')2 goat anti-mouse immunoglobulin (IgM) for 24 or 48 h also presented antigen (Ag) to Th1 cells in a manner that induced dramatic Ag-specific proliferative inactivation. The tolerogenicity of the anti-Ig-t...
متن کاملCD40 and B cell antigen receptor dual triggering of resting B lymphocytes turns on a partial germinal center phenotype
Phenotypic alterations occur when resting human B lymphocytes become germinal center (GC) cells. These include the induction of surface CD38, CD95 (FAS/APO-1), and carboxy-peptidase-M (CPM), a recently described GC marker. However, the factors that govern the in vivo induction of these surface molecules on B cells remain unknown. Here, we purified resting (CD38-) human B lymphocytes from tonsil...
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ژورنال
عنوان ژورنال: Cell Communication and Signaling
سال: 2009
ISSN: 1478-811X
DOI: 10.1186/1478-811x-7-s1-a26